Azelastine hydrochloride

SKU: orb1310831

Description

Azelastine hydrochloride is a phthalazinone-based compound that acts as a histamine H1 receptor antagonist. It is widely used in pharmacological research for studying allergic responses and inflammation in both in vitro cellular assays and in vivo animal models.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	79307-93-0
MW	418.36
Purity	>99.99% (May vary between batches)
Formula	C₂₂H₂₄ClN₃O·HCl
SMILES	Cl.CN1CCCC(CC1)n1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O
Target	Histamine Receptor,SARS-CoV
Solubility	H2O:35 mg/mL (83.66 mM);Ethanol:57 mg/mL (136.25 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.89 mM);DMSO:84 mg/mL (200.78 mM)

Bioactivity

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In Vivo

In the rat basophilic leukemia RBL-2H3 cell line, Azelastine inhibited antigen (Ag)-induced TNF-alpha release (IC50=25.7 mM) and ionomycin-induced TNF-alpha release (IC50=1.66 mM). In mouse peritoneal macrophages, Azelastine suppressed inducible nitric oxide synthase (iNOS) mRNA expression and nitric oxide (NO) production. In normal human mast cells, Azelastine inhibited the secretion of IL-6, TNF-alpha, and IL-8, and the activation of NF-κB, as well as intracellular calcium levels. In human gingival fibroblasts, Azelastine dose-dependently inhibited DNA and protein synthesis.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Histamine Receptor, HistamineReceptor, Inhibitor, H1 receptor, inhibit, Optivar, antihistamine, Astelin, asthma, Azelastine, Azelastine HCl, Azelastine hydrochloride, Azelastine Hydrochloride, Allergodil, allergic rhinitis, SARS coronavirus, SARSCoV, SARS-CoV

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Compound Identifiers

PubChem CID

54360 ↗

Key Properties

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No computed properties available.

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