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Barbadin

SKU: orb1707595

Description

Barbadin is a specific inhibitor of β-arrestin/β2-adaptin interactions, blocking agonist-promoted endocytosis of GPCRs like the β2-adrenergic receptor. It has been used in research on obesity, demonstrating in vivo effects such as potentiating lorcaserin-induced weight loss in animal models.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number356568-70-2
MW333.41
Purity99.10%
FormulaC19H15N3OS
SMILESNn1cnc2scc(-c3ccc(Cc4ccccc4)cc3)c2c1=O
TargetArrestin,Apoptosis
SolubilityDMSO:60 mg/mL (179.96 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6 mM)

Bioactivity

Target IC50
β-arrestin1:19.1 μM|β-arrestin2:15.6 μM

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Barbadin, β-arrestin2, β-arrestin, β-arrestin1

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Key Properties

No computed properties available.

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Barbadin (orb1707595)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,170.00
5 mg
¥ 2,210.00
1 ml x 10 mM (in DMSO)
¥ 2,470.00
10 mg
¥ 3,120.00
25 mg
¥ 4,810.00
50 mg
¥ 6,890.00
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