CDDO-Me

SKU: orb1301019

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Description

Bardoxolone Methyl (TP-155) is a synthetic triterpenoid that activates the Nrf2 antioxidant pathway while inhibiting the pro-inflammatory NF-κB pathway. It has demonstrated anti-inflammatory and potential anti-tumor activity in various in vitro and in vivo research models, including studies on kidney disease and cancer.

Research Area

Cancer Biology, Cell Biology

Images & Validation

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Key Properties

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CAS Number	218600-53-4
MW	505.7
Purity	>98%
Formula	C₃₂H₄₃NO₄
SMILES	[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2C(=O)C=C2[C@@]1(C)CC[C@@]1([H])C(C)(C)C(=O)C(=C[C@]21C)C#N)C(=O)OC
Target	Transcription factor
Solubility	Soluble in DMSO (25 mg/ml, warm)

Bioactivity

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In Vivo	Bardoxolone Methyl (60 mg/kg) reduces the number, size, and severity of lung tumors in vivo. Bardoxolone Methyl significantly reduces the in vivo inflammatory cytokine response following LPS challenge, induces HO-1 protein expression in the spleen, and protects mice against lethal-dose LPS. Read more...
In Vitro	Bardoxolone Methyl exhibits potent inhibitory activities against production of nitric oxide induced by interferon- in mouse macrophages with IC50 of 0.1 nM. Bardoxolone Methyl decreases the viability of leukemic HL-60, KG-1, and NB4 cells with IC50 of 0.4, 0.4, and 0.27 μM, respectively. CDDO-Me induces pro-apoptotic Bax protein, inhibits the activation of ERK1/2, and it blocks Bcl-2 phosphorylation, which contributes to the induction of apoptosis. Bardoxolone Methyl potently inhibits both constitutive and inducible NF-kappaB activated by TNF, interleukin (IL)-1beta, phorbol ester, okadaic acid, hydrogen peroxide, lipopolysaccharide, and cigarette smoke. Read more...
Cell Research	Leukemic cell lines are cultured at a density of 3.0 × 105 cells/mL, and AML mononuclear cells are cultured at 5 × 105 cells/mL in the presence or absence of indicated concentrations of CDDO-Me. Appropriate amounts of DMSO (final concentration less than 0.05%) are included as control. For cytotoxicity studies, 1 μM ara-C is added to the cultures. After 24 to 72 hours, viable cells are counted with the trypan blue dye exclusion method using a hematocytometer. (Only for Reference) Read more...

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Bardoxolone methyl; RTA 402; TP-155; CDDO-Methyl ester

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Compound Identifiers

PubChem CID

70700216 ↗

Key Properties

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No computed properties available.

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CDDO-Me (orb1301019)

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CDDO-Me

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

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Protocol Information

CDDO-Me (orb1301019)

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