Cart summary

You have no items in your shopping cart.

BAY-4931

SKU: orb1741340

Description

BAY-4931 is a potent, covalent, and selective PPARγ inverse-agonist with an IC50 of 0.17 nM. This research compound is a valuable tool for investigating PPARγ's role in metabolic diseases, such as diabetes and obesity, in both cellular and animal models.

Research Area

Metabolism Research, Molecular Biology

Images & Validation

Key Properties

CAS Number423150-91-8
MW421.83
Purity99.73%
FormulaC22H16ClN3O4
SMILESN(C(=O)C1=CC(N(=O)=O)=CC=C1Cl)C=2C=C3C(OC(=N3)C4=CC=C(CC)C=C4)=CC2
TargetPPAR
SolubilityDMSO:112.5 mg/mL (266.7 mM)

Bioactivity

Target IC50
PPARγ(RT112-FABP4-NLucP cellular):0.17 nM|PPARγ (human):0.40 nM|UM-UC-9 cells:3.4 nM|PPARγ (mouse):0.14 nM
In Vitro
Fractionation of culture extracts using RP-HPLC and LC-MS showed that samples containing Questin was toxic to the human A549 lung cell line.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

BAY4931, BAY-4931, BAY 4931, PPARγ
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

BAY-4931 (orb1741340)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,040.00
5 mg
¥ 1,560.00
1 ml x 10 mM (in DMSO)
¥ 1,820.00
10 mg
¥ 2,210.00
25 mg
¥ 4,290.00
50 mg
¥ 6,500.00
100 mg
¥ 9,360.00
500 mg
¥ 19,110.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry