Cart summary

You have no items in your shopping cart.

BBIQ

SKU: orb1707584

Description

BBIQ is a potent and selective TLR7 agonist (EC50 = 59.1 nM for human TLR7) that functions as a powerful vaccine adjuvant by enhancing innate immune responses. Its application spans vaccine research and immunology studies, facilitating investigations into TLR7-mediated signaling in both cellular assays and animal models.

Research Area

Immunology & Inflammation

Images & Validation

−
BBIQ

Key Properties

−
CAS Number1229024-57-0
MW330.43
Purity99.71%
FormulaC21H22N4
SMILESC(N1C=2C=3C(N=C(N)C2N=C1CCCC)=CC=CC3)C4=CC=CC=C4
TargetTLR
SolubilityDMSO:3.31 mg/mL (10.02 mM)

Bioactivity

−
Target IC50
TLR7 (human):59.1 nM (EC50)
In Vivo
In an experimental study, mice that received only Chloroquine (CQ) for treatment showed signs of the parasite (P. berghei ANKA) by Day 17 and succumbed by Day 21. Conversely, those administered a combination of BBIQ and CQ did not exhibit any parasitic presence up to Day 23. Additionally, the combined treatment with BBIQ + CQ resulted in a reduction of T cell frequencies (CD3+, CD4+, and CD8+) and T regulatory cell frequencies (CD4+, CD25+, and FoxP3+) in the brain when compared to the effects of BBIQ or CQ alone on Day 10. This treatment also elevated the serum levels of IFN-γ and IL-12, indicating a strong Th1 immune response against the infection on the same day. The study suggests that the BBIQ + CQ combination therapy not only inhibits the infiltration of inflammatory T cells but also activates T helper and T cytotoxic cells to combat the parasite effectively.
Read more...
In Vitro
BBIQ induces IFN-α in human PBMCs (520 pg/mL at 5 µg/mL).

Storage & Handling

−
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

−
TLR7, BBIQ

Similar Products

−
  • m-AM-BBIQ

    m-AM-BBIQ [orb2664391]

    1258457-58-7

    359.47

    C22H25N5

    50 mg, 25 mg, 100 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
46830489 ↗

Key Properties

−
No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Find More Protocols

BBIQ (orb1707584)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Login to review

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 ml x 10 mM (in DMSO)
¥ 910.00
25 mg
¥ 1,170.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry
Need technical support? Find your Distributor Return and Tax Policy

Email

[email protected]

UK Office

+44 (0)1223 859353

US Office

+1 (415) 906-5211

CN Office

+86 (27)-87663101

Distributors

biorbyt.com/distributor