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BC-1258

SKU: orb1218765

Description

BC-1258 is a unique small molecule F-box/LRR-repeat protein 2 (FBXL2) activator.

Images & Validation

Key Properties

CAS Number1507370-40-2
MW406.57
Purity>98% (HPLC)
FormulaC22H22N4S2
SMILESC1=CC(=CC=C1CNCCNCC2=CC=C(C=C2)C3=NC=CS3)C4=NC=CS4
TargetFBXL2
SolubilityDMSO:10 mM

Bioactivity

In Vivo
BC-1258 (30 μg/mL in the drinking water) significantly reduces tumor size and weight in athymic nude mice.
In Vitro
Cell Cycle Analysis Cell line: MLE cells. Concentration: 2, 10, 50 μg/mL. Incubation time: 16 hours. Result: Significantly increased the cell population within the G2/M phase. Reduced the diploid cell population and increase the numbers of polyploidal cells in a dose-dependent manner. Western blot analysis. Cell line: U937, K562 and THP1 cells. Concentration: 2, 10 μg/mL. Incubation time: 16 hours. Result: Increased FBXL2 protein levels. Decreased FBXL2 substrates, including Aurora B, cyclin D2 and cyclin D3 levels.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • BC-​1258 [orb1298494]

    99.99% (May vary between batches)

    1507370-40-2

    406.57

    C22H22N4S2

    5 mg, 10 mg, 25 mg, 50 mg, 1 ml x 10 mM (in DMSO)
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BC-1258 (orb1218765)

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Available Sizes

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100 mg
200 mg
500 mg
5 mg
¥ 1,170.00
10 mg
¥ 1,690.00
25 mg
¥ 3,120.00
50 mg
¥ 4,810.00