Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

Bemnifosbuvir

SKU: orb1298170

Description

Bemnifosbuvir (AT-511) is a phosphoramidate prodrug of a 2'-C-methylguanosine monophosphate analog, demonstrating potent anti-HCV activity in vitro. It is a research compound used in virology and antiviral drug discovery, with studies investigating its efficacy in both cell-based assays and animal models of hepatitis C infection.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Images & Validation

−
Bemnifosbuvir

Key Properties

−
CAS Number1998705-64-8
MW581.53
Purity99.35% (May vary between batches)
FormulaC24H33FN7O7P
SMILESC[C@]1(F)[C@H](N2C=3C(N=C2)=C(NC)N=C(N)N3)O[C@H](COP(OC4=CC=CC=C4)(N[C@H](C(OC(C)C)=O)C)=O)[C@H]1O
TargetHCV Protease|||SARS-CoV
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.67 mM);DMSO:95 mg/mL (163.36 mM)

Customer Validated Data

−
The data below is submitted by researchers worldwide. We provide this transparency to help you decide if this product works for your specific application or species, even if we haven't tested it ourselves.
Success by Application
Reactivity Distribution

Latest Experiments

1 Results
Dilution
Sample
Summary
Cell culture
Human
-
S10-3 cells
Cells were inoculated with HEV in...

Bioactivity

−
Target IC50
SARS-CoV-2:0.47 μM (EC90)|HCV:5-28 nM (EC50)
In Vivo
Treatment with moxifloxacin every 8hr was accompanied by longer survival than in any other group.Tissue cultures 30hr after bacterial challenge showed considerably less bacterial growth in the spleens and lungs of moxifloxacin-treated animals than in the other groups, but not in their livers.
In Vitro
Bemnifosbuvir is a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate that has potent in vitro activity against HCV.In the absence of cells, Bemnifosbuvir was stable when incubated in culture medium at 37°C for up to 24 h. AT-9010 was the predominant intracellular metabolite measured in all hepatocyte species and Huh-7 cell incubations with 10 μM Bemnifosbuvir and, except in mouse hepatocytes,far exceeded intracellular Bemnifosbuvir concentrations,demonstrating that the active TP was efficiently formed from its phosphoramidate protide in liver cells. In hepatocyte incubations, the relative levels of AT-9010 formed, and its accumulation over 24 h expressed as area under the curve or AUC0-24h; from most to least abundant, were rat>human >mouse >dog/monkey.

Storage & Handling

−
Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

−
phosphoramidate, SARS-CoV, SARSCoV, SARS coronavirus, Bemnifosbuvir, antiviral, AT 511, AT511, AT-511, Inhibitor, Hepatitis C virus, HCVProtease, HCV Protease, HCV, guanosine, inhibit, nucleotide, pangenotypic

Similar Products

−

  • Bemnifosbuvir hemisulfate [orb1298178]

    99.98% (May vary between batches)

    2241337-84-6

    1261.15

    C48H68F2N14O18P2S

    1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg

  • Bemnifosbuvir hemisulfate [orb1218400]

    >98% (HPLC)

    2241337-84-6

    1261.15

    C48H68F2N14O18P2S

    5 mg, 10 mg, 25 mg, 100 mg, 500 mg, 50 mg, 1 g, 200 mg

  • Bemnifosbuvir [orb1940237]

    >98% (HPLC)

    1998705-64-8

    581.53

    C24H33FN7O7P

    50 mg, 100 mg, 200 mg, 500 mg, 1 g, 5 mg, 10 mg, 25 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
122527455 ↗

Key Properties

−
No computed properties available.

Protocol Information

Find More Protocols

Available Sizes

Select a size below

1 mg
$ 100.00
5 mg
$ 190.00
10 mg
$ 290.00
1 ml x 10 mM (in DMSO)
$ 360.00
25 mg
$ 460.00
50 mg
$ 640.00
100 mg
$ 840.00
200 mg
$ 1,170.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry
Need technical support? Find your Distributor Return and Tax Policy

Email

[email protected]

UK Office

+44 (0)1223 859353

US Office

+1 (415) 906-5211

CN Office

+86 (27)-87663101

Distributors

biorbyt.com/distributor