Bicuculline

SKU: orb1304933

Description

Bicuculline is a natural alkaloid that acts as a competitive GABAA receptor antagonist (IC50 = 2 µM) and a blocker of SK potassium channels. It is widely utilized in neuroscience research to induce seizures in animal models and to study synaptic inhibition and neuronal excitability in vitro.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	485-49-4
MW	367.35
Purity	98.00% (May vary between batches)
Formula	C₂₀H₁₇NO₆
SMILES	[H][C@]1(OC(=O)c2c3OCOc3ccc12)[C@@]1([H])N(C)CCc2cc3OCOc3cc12
Target	GABA Receptor
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.44 mM);DMSO:16.67 mg/mL (45.38 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

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Target IC50

GABAA receptor:2 μM

In Vivo

(+)-Bicuculline, at concentrations of 1/3 μM, increased the EC50 of gamma-aminobutyric acid (GABA) by 1.6 times (41.0-67.0 μM) and by 3.6 times (36.1-129.0 μM), respectively. This compound also dose-dependently inhibited the Cl- conductance induced by GABA (40 μM) in the range of 1-100 μM. In addition, (+)-Bicuculline inhibited the agonistic effects of GABA (40 μM) on the α1β2γ2L receptor, functioning as an antagonist of the α1β2γ2L GABAA receptor. This action caused a parallel shift in the concentration-effect curve of GABA without affecting its maximum response. Furthermore, (+)-Bicuculline also exhibited inhibitory effects on Ca2+-activated potassium channels.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Bicuculline, (+)-Bicuculline, AHP, alkaloid, d-Bicuculline, convulsant, competitive, inhibit, neurotransmitter, Inhibitor, GABAR, GABA Receptor, GABAReceptor, Gamma-aminobutyric acid Receptor, potassium, γ-Aminobutyric acid Receptor

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Compound Identifiers

PubChem CID

10237 ↗

Key Properties

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No computed properties available.

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Bicuculline (orb1304933)

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Purity:	99.35% (May vary between batches)
CAS Number:	38641-83-7
MW:	417.84
Formula:	C₂₁H₂₀ClNO₆

Purity:	99.24% (May vary between batches)
CAS Number:	40709-69-1
MW:	509.29
Formula:	C₂₁H₂₀INO₆

CAS Number:	66016-70-4
MW:	462.29
Formula:	C₂₁H₂₀BrNO₆

Purity:	99.25% (May vary between batches)
MW:	516.59
Formula:	C₂₉H₃₂N₄O₅

CAS Number:	53552-05-9
MW:	417.84
Formula:	C₂₁H₂₀ClNO₆

Bicuculline

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Bicuculline (orb1304933)

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