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Bigelovin

SKU: orb1297012

Description

Bigelovin

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

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Bigelovin

Key Properties

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CAS Number3668-14-2
MW304.34
Purity99.40% (May vary between batches)
FormulaC17H20O5
SMILES[H][C@]12C[C@@H](C)[C@]3([H])C=CC(=O)[C@@]3(C)[C@@H](OC(C)=O)[C@@H]1C(=C)C(=O)O2
TargetReactive Oxygen Species|||Apoptosis|||Retinoid Receptor|||RAR/RXR |||Autophagy
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.57 mM);DMSO:60 mg/mL (197.15 mM)

Bioactivity

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In Vivo
In vivo studies demonstrated that BigV significantly suppressed the growth of HepG2 cancer xenograft tumors through the activation of apoptosis and autophagy in a dose-dependent manner with low systemic toxicity. Revealed that BigV had significant antitumor effects against human liver cancer and it may potentially be used as a novel antitumor agent for the prevention of liver cancer.
In Vitro
BigV exhibited potential anti-tumor activities against human liver cancer in vitro and in vivo. BigV reduced the cell proliferation and colony formation. BigV induced apoptosis through improving the cleavage of Caspase-3 and poly (ADP-ribose) polymerase 1 (PARP-1). The process was along with the activation of autophagy, as proved by the enhanced accumulation of autophagosomes, the microtubule-associated light chain 3B-II (LC3B-II) and Beclin-1, and p62 decrease. Further, the autophagy blockage markedly sensitized BigV-induced cell death, indicating the cytoprotective function of autophagy in liver cancer cell lines. In addition, BigV treatment inactivated the pathway of protein kinase B (AKT)/mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K). Of note, BigV-induced cell death was abolished by over-expressing the phosphorylation of mTOR. Intriguingly, the induction of apoptosis and autophagy were eliminated by the pretreatment of reactive oxygen species (ROS) scavenger N-acetyl-l-cysteine (NAC), suggesting that ROS played an important role in the regulation of BigV-induced cell death.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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RAR, RAR/RXR, Reactive Oxygen Species, ReactiveOxygenSpecies, Retinoic acid receptors, Retinoid X receptors, retinoid X receptor α, Retinoid Receptor, RetinoidReceptor, RXR, inhibit, Inhibitor, Apoptosis, Autophagy, Bigelovin

Similar Products

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  • Bigelovin [orb1218100]

    >98% (HPLC)

    3668-14-2

    304.34

    C17H20O5

    5 mg, 50 mg, 10 mg, 1 g, 200 mg, 500 mg, 25 mg, 100 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
3080597 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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1 mg
$ 140.00
1 ml x 10 mM (in DMSO)
$ 270.00
5 mg
$ 270.00
10 mg
$ 340.00
25 mg
$ 560.00
50 mg
$ 780.00
100 mg
$ 1,030.00
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