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BIO

SKU: orb1224292

Description

A cell-permeable derivative of 6-bromoindirubin that displays selective inhibition of GSK-3 with IC50 of 5 nM; also inhibit CDK1/Cyclin B and CDK5/p25 (IC50, 320 nM and 83 nM); maintains the undifferentiated phenotype in HESCs and MESCs, sustains the expression of Oct-3/4, Rex-1 and Nanog; promotes proliferation in mammalian cardiomyocytes.

Images & Validation

Key Properties

CAS Number667463-62-9
MW356.1735
Purity>98% (HPLC)
FormulaC16H10BrN3O2
SMILESO=C(/C1=C2NC3=C(C\2=N/O)C=CC=C3)NC4=C1C=CC(Br)=C4
TargetGSK-3
SolubilityDMSO: ≥ 23 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

6BIO | 6-BIO | GSK 3 IX | GSK 3 Inhibitor IX | MLS 2052 | MLS2052

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Protocol Information

Available Sizes

Select a size below

2 mg
$ 100.00
5 mg
$ 140.00
10 mg
$ 180.00
25 mg
$ 390.00
50 mg
$ 680.00
100 mg
$ 1,000.00
500 mg
$ 2,110.00