Bivamelagon hydrochloride

SKU: orb1944348

Description

Bivamelagon hydrochloride is a selective MC4R agonist (EC50=36.5 nM, Ki=65 nM) with the advantages of oral available and blood-brain barrier penetration, suitable for obesity and diabetes research.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	2641595-55-1
MW	665.73
Purity	100.00%
Formula	C₃₅H₅₄Cl₂N₄O₄
SMILES	C(=O)(N1[C@H](C(=O)N2CCOCC2)C[C@H](N(C(C(C)C)=O)[C@@H]3CC[C@H](C)CC3)C1)[C@H]4[C@@H](CN(C(C)(C)C)C4)C5=CC=C(Cl)C=C5.Cl
Target	Melanocortin Receptor

Bioactivity

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Target IC50	MC4R:65 nM (Ki)
In Vitro	In U2OS cells expressing MC4R and β-arrestin, Bivamelagon hydrochloride (Example 1) (90 min) demonstrated β-arrestin recruitment activity, with a corresponding EC50 of 4.6 nM . Read more...

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Melanocortin Receptor, MelanocortinReceptor, MC-4R Agonist 2 hydrochloride

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Compound Identifiers

PubChem CID

168679814 ↗

Key Properties

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No computed properties available.

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