BML-190

SKU: orb1300787

Description

BML-190 is a selective CB2 receptor inverse agonist with a Ki of 435 nM, exhibiting 50-fold selectivity over the CB1 receptor. This compound is a valuable research tool for studying CB2 receptor function in both in vitro and in vivo models of inflammation and neuropathic pain.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	2854-32-2
MW	426.89
Purity	99.51% (May vary between batches)
Formula	C₂₃H₂₃ClN₂O₄
SMILES	COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)N3CCOCC3)c2c1
Target	Cannabinoid Receptor
Solubility	DMSO:21 mg/mL (49.19 mM);10% DMSO+90% Corn Oil:2 mg/mL (4.69 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

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Target IC50	CB2:435 nM(Ki)
In Vitro	BML-190 has 50-fold selectivity for CB2 receptors over CB1 receptors. In HEK-293 cells stably expressing the human CB2 receptor, BML-190 potentiates the forskolin-stimulated accumulation of cAMP. BML-190 reduces the basal levels of inositol phosphate production in cells expressing the CB2 receptor. 10 μM of BML-190 decreases inositol phosphates accumulation by 38%. BML-190 is an aminoalkylindole. BML-190 is found to yield at least 15 metabolic products. BML-190 diminishes LPS-induced NO and IL-6 production in a concentration-dependent manner. BML-190 also inhibits LPS-induced PGE2 production and COX-2 induction. Read more...
Cell Research	293/CB2 cells are labeled with [3H]adenine (1 μCi/mL) in MEM with 1% FBS for 20 hours-24 hours. Labelled cells are challenged with 50 μM forskolin and appropriate BML-190 for 30 minutes at 37°C and assayed for cAMP accumulation. For IP assays, 2 × 105 293/CB2 cells are transiently transfected with 16z44 and/or pcDNA3 using transfection reagents. Cells are labelled, challenged with BML-190 and assayed for IP production. Triplicates are performed for each data point and at least three separate trials are done for each ligand.(Only for Reference) Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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CB, CB2, BML 190, BML190, BML-190, Cannabinoid Receptor, CannabinoidReceptor, Inhibitor, inhibit, Indomethacin morpholinylamide, IMMA

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Compound Identifiers

PubChem CID

2415 ↗

Key Properties

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No computed properties available.

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BML-190 (orb1300787)

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Purity:	>98% (HPLC)
CAS Number:	2854-32-2
MW:	426.9
Formula:	C₂₃H₂₃ClN₂O₄

BML-190

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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