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BML-284

SKU: orb1304496

Description

BML-284 (Wnt agonist 1) is a cell-permeable, selective small molecule that potently activates Wnt/β-catenin signaling. It is widely used in vitro to study stem cell biology, tissue regeneration, and oncogenesis, and has been applied in vivo within bone and cartilage research models.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number853220-52-7
MW350.37
Purity99.66% (May vary between batches)
FormulaC19H18N4O3
SMILESCOc1cccc(c1)-c1cc(NCc2ccc3OCOc3c2)nc(N)n1
TargetWnt/beta-catenin
SolubilityDMSO:255 mg/mL (727.8 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.71 mM)

Bioactivity

Target IC50
TCF-dependent transcriptional activity:700 nM (EC50)
In Vivo
In a Xenopus model, Wnt agonist 1 (10 μM) mimics the effects of Wnt at the whole-organism level, and affects Xenopus embryonic head specification.
In Vitro
Wnt agonist 1 does not inhibit the activity of GSK-3β, and may be a useful tool in the study of physiological processes that involve the Wnt pathway.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

betacatenin, beta-catenin, AGS, BML 284, BML284, BML-284, bcatenin, cardiac defect, E-cadherin, Inhibitor, malformed phenotype, inhibit, N-cadherin, MNK45, Wnt agonist 1, Wnt, Wnt/betacatenin, Wnt/b-catenin, Wnt/β-catenin, TCF, βcatenin

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

5 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 110.00
10 mg
$ 120.00
25 mg
$ 190.00
50 mg
$ 310.00
100 mg
$ 490.00
200 mg
$ 690.00
500 mg
$ 1,030.00
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