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BMS-564929

SKU: orb1707535

Description

BMS-564929 is a potent androgen receptor agonist that promotes lipogenic enzyme activity while reducing visceral adipose tissue and lipid content. It downregulates key lipogenic genes including acetyl-CoA carboxylase, FASN, and SCD, making it a valuable research tool for studying metabolic disorders in both in vitro and in vivo models.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number627530-84-1
MW305.72
Purity98.17%
FormulaC14H12ClN3O3
SMILESO=C1N(C(=O)N2[C@]1([C@H](O)CC2)[H])C3=C(C)C(Cl)=C(C#N)C=C3
TargetAndrogen Receptor
SolubilityDMSO:40 mg/mL (130.84 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.54 mM)

Bioactivity

Target IC50
AR:2.11 nM (Ki)
In Vivo
BMS-564929 (0.00001 - 10 mg/kg,14 days, gavage) is more effective than testosterone in stimulating the growth of the levator anal muscle and has a strong oral activity.
In Vitro
BMS-564929 is a novel, highly effective and orally active non-steroidal tissue-selective androgen receptor (AR) modulator with Ki = 2.11 nM. The EC50 value of BMS-564929 in mouse myoblasts (C2C12) and rat PEC cell lines was 0.44 nM and 8.66 nM, respectively.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

BMS564929, BMS-564929, BMS 564929, AndrogenReceptor
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

BMS-564929 (orb1707535)

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% DMSO +
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% Tween 80 +
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2 mg
¥ 2,470.00
DispatchUsually dispatched within 5-10 working days
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