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BMS-986339

SKU: orb1744391

Description

BMS-986339 is a potent, orally bioavailable FXR agonist that forms key hydrogen bonds with residues His298 and Asn287. Its anti-fibrotic properties are being investigated in preclinical research for liver diseases including NASH, PBC, and PSC, utilizing both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number2477873-64-4
MW643.71
FormulaC35H41F4N3O4
SMILESC(C)(C)(F)C1=NC(C23CCC(CN(C(=O)[C@H]4C[C@@](C(F)(F)F)(O)C4)C5=CC(=CC=C5)C6=CC=C(C(C)(C)O)C=C6)(CC2)CC3)=NO1
TargetFXR,Cytochromes P450,Others

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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Protocol Information

BMS-986339 (orb1744391)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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