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BMS453

SKU: orb1704988

Description

BMS-189453 is a synthetic retinoid and potent RARβ-selective agonist. It acts as a testicular toxin and inhibits breast cell growth primarily by inducing active TGFβ. This compound is used in research fields such as oncology and toxicology for in vitro and in vivo studies of retinoid signaling and TGFβ-mediated growth inhibition.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number166977-43-1
MW380.48
Purity99.78% (May vary between batches)
FormulaC27H24O2
SMILESCC1(C)CC=C(c2ccccc2)c2cc(\C=C\c3ccc(cc3)C(O)=O)ccc12
TargetRetinoid Receptor
SolubilityDMSO:45 mg/mL (118.27 mM)

Bioactivity

In Vitro
BMS453 (1 μM; 11 hours; 184 and HMEC cells) inhibits normal breast cell proliferation without significantly inducing apoptosis. The RARβ-selective agonist (BMS453) significantly reduces T47D breast cancer cell migration to levels comparable to RA inhibition, unlike RARα- or RARγ-selective agonists (BMS753 and BMS961), indicating RARβ's role in RA-inhibited cell migration.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

RAR/RXR, RARα, RARβ, RARγ, TGFβ, RetinoidReceptor, Retinoid Receptor, Retinoid X receptors, Retinoic acid receptors, retinoid, Inhibitor, inhibit, cell, breast, BMS 453, BMS 189453, BMS453, BMS-453, BMS189453, BMS-189453, arrest
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

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5 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 140.00
10 mg
$ 140.00
25 mg
$ 260.00
50 mg
$ 370.00
100 mg
$ 510.00
DispatchUsually dispatched within 3-5 working days
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