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BMS493

SKU: orb1707523

Description

BMS493 is a pan-retinoic acid receptor (RAR) inverse agonist that suppresses RA-mediated differentiation and signaling by recruiting co-repressors. It is utilized in research to study retinoid pathways, including in models of development and toxicity, such as enhancing TPP-induced effects.

Research Area

Metabolism Research

Images & Validation

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BMS493

Key Properties

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CAS Number215030-90-3
MW404.5
Purity99.12% (May vary between batches)
FormulaC29H24O2
SMILESCC1(C)CC=C(C#Cc2ccccc2)c2cc(\C=C\c3ccc(cc3)C(O)=O)ccc12
TargetPhospholipase,Retinoid Receptor
SolubilityDMSO:30 mg/mL (74.17 mM)

Bioactivity

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In Vivo
In contrast to freshly isolated ALDHhi cells, 6-day expansion with or without BMS 493 generated progeny that were unable to reduce hyperglycemia after iPan transplantation into STZ-treated NOD/SCID mice.
In Vitro
Cells treated with BMS 493 (100 nM; 6 days) showed a twofold increase in the number of ALDHhi cells available for transplantation compared to untreated controls. Newly expanded ALDHhi cells exhibited increased numbers of CD34 and CD133-positive cells, along with a reduction in CD38 expression.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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BMS 493, BMS493, BMS-493, RAR, phospholipase A2, Retinoid Receptor, RetinoidReceptor
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
9909190 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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2 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 140.00
DispatchUsually dispatched within 5-10 working days
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