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BMY-14802 hydrochloride

SKU: orb1704654

Description

BMY-14802 hydrochloride is a σ receptor antagonist (IC50 = 112 nM) with additional agonist activity at α1-adrenergic and 5-HT1A receptors. It has been investigated in preclinical in vivo studies for its potential antipsychotic properties and used in vitro to probe sigma receptor function.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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BMY-14802 hydrochloride

Key Properties

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CAS Number105565-55-7
MW384.85
Purity98.64% (May vary between batches)
FormulaC18H23ClF2N4O
SMILESCl.OC(CCCN1CCN(CC1)c1ncc(F)cn1)c1ccc(F)cc1
TargetAdrenergic Receptor,5-HT Receptor,Sigma receptor
SolubilityH2O:9 mg/mL (23.39 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.2 mM)

Bioactivity

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Target IC50
σ receptor:112 nM (IC50)
In Vivo
Intraperitoneal administration of BMY-14802 hydrochloride (5-20 mg/kg) shows anti-dyskinetic efficacy across a 4-fold dose range against L-DOPA-induced dyskinesias without affecting the efficacy of L-DOPA against lesion-induced akinesia. BMY-14802 hydrochloride reduces D1 and D2 receptor agonist-induced dyskinesias.
In Vitro
BMY-14802 hydrochloride shows effects on the firing of 5-HTergic and catecholaminergic neurons and affects behaviors in a 5-HT1A-sensitive manner.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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BMS181100 Hydrochloride, BMS-181100 Hydrochloride, BMS 181100 Hydrochloride, BMS 181100 hydrochloride, BMY14802 Hydrochloride, BMY-14802 Hydrochloride, BMY-14802-1, BMY 14802 hydrochloride, BMY 14802 Hydrochloride, 5HT Receptor, 5-HT1A, AdrenergicReceptor, Adrenergic Receptor, 5HTReceptor, Sigma receptor, Sigmareceptor, α1-adrenergic receptor, σ
Quality Guarantee

Quality Guarantee

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Compound Identifiers

PubChem CID
3086514 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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5 mg
$ 70.00
10 mg
$ 90.00
25 mg
$ 150.00
50 mg
$ 220.00
100 mg
$ 300.00
200 mg
$ 410.00
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