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BMY 7378 free base

SKU: orb3028976

Description

BMY 7378 (free base) is a selective antagonist for the α1D adrenergic receptor (α1D-AR). It exhibits a membrane-binding affinity for cloned rat α1D-AR (Ki=2 nM) that is over 100 times stronger than its affinity for cloned rat α1A-AR (Ki=800 nM) or hamster α1B-AR (Ki=600 nM). Additionally, BMY 7378 (free base) acts as a partial agonist at the 5-HT1A receptor.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number21102-94-3
MW385.5
FormulaC22H31N3O3
SMILESO=C1N(C(=O)CC2(C1)CCCC2)CCN3CCN(C=4C=CC=CC4OC)CC3
TargetAdrenergic Receptor,5-HT Receptor

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information