(+)-BORNEOL

SKU: orb1301541

Description

(+)-Borneol is a bicyclic monoterpene utilized in traditional medicine for its analgesic and anesthetic properties. Research indicates it acts as a positive allosteric modulator of GABA_A receptors, with an EC50 of 248 μM, supporting its study in neuropharmacology and for potential therapeutic applications.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	464-43-7
MW	154.25
Purity	≥95% (May vary between batches)
Formula	C₁₀H₁₈O
SMILES	CC1(C)[C@@H]2CC[C@@]1(C)[C@@H](O)C2
Target	Endogenous Metabolite,GABA Receptor
Solubility	DMSO:247.5 mg/mL (1604.54 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (25.93 mM)

Bioactivity

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Target IC50	GABA:248 μM(EC50)
In Vivo	(+)-borneol (1.0 mg/kg) significantly ameliorated infarct size and neurological scoresvia reducing the expression of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-α) in a dose dependent manner. Notably, (+)-borneol showed long-term effects on the improvement of sensorimotor functions in the photothrombotic model of stroke, which decreased the number of foot faults in the grid-walking task and forelimb asymmetry scores in the cylinder task, at least in part through reducing loss of dendritic spines in the length, brunch number and density. Suggest that (+)-borneol could serve as a therapeutic target for ischemic stroke. Read more...
In Vitro	Aβ-induced cell cytotoxicity was inhibited by 100 μM of (-) and (+) borneol treatment. Treatment of borneol significantly decreased ROS generation (P < 0.01). The expression of HO-1 and nuclear translocation of Nrf2 were increased by Aβ treatment. This nuclear translocation of Nrf2 was further increased by administration of borneol. Compared with the Aβ treated group, the (+) borneol treated group significantly increased Bcl-2 expression with decreased expression of Bax. Read more...
Cell Research	Oxidative stress was induced by administering 50 μM Aβ into SH-SY5Y cells. Neuroprotective effect of commercially available borneol was examined by determining cell viability with the MTT assay. Intracellular reactive oxygen species (ROS) generation was measured using a fluorometer with further examination of heme oxygenase-1 (HO-1) and nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) expression. Apoptosis was examined by measuring the ratio of B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein (Bax). Read more...
Animal Research	To mimic a typical human stroke, which does not undergo reperfusion, used a permanent MCAO in this study. For investigating the role of (+)-borneol in permanent cerebral ischemia, 45 male Sprague-Dawley rats were randomly divided into the sham group, the vehicle-treated group and the (+)-borneol-treated groups (1.0 mg/kg), with 15 rats in each group. The terminal half-life (t1/2) of borneol was 2 h following cerebral ischemia-reperfusion. We subjected the rats to pMCAO and administered drugs by tail intravenous injection 2 hours and 5 hours after pMCAO, respectively. The sham group and the vehicle-treated group were injected with vehicle administration. Neurologic scores were assessed at 48 hours after reperfusion. Read more...

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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GABA, GABA Receptor, GABAReceptor, BORNEOL, (+) BORNEOL, (+)BORNEOL, d-Borneol

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Compound Identifiers

PubChem CID

6552009 ↗

Key Properties

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No computed properties available.

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(+)-BORNEOL (orb1301541)

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Purity:	98.5%（GC）
CAS Number:	464-43-7

Purity:	> 98%,Standard References
CAS Number:	507-70-0
MW:	154.25
Formula:	C₁₀H₁₈O

Purity:	99.02% (May vary between batches)
CAS Number:	464-45-9
MW:	154.25
Formula:	C₁₀H₁₈O

Purity:	98.84% (May vary between batches)
CAS Number:	90-24-4
MW:	196.2
Formula:	C₁₀H₁₂O₄

(+)-BORNEOL

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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