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Brazilin

SKU: orb1222224

Description

Brazilin exhibits anti-hepatotoxic, antiplatelet effects. Brazilin has cancer preventive effect, may inhibit T24 cell growth and trigger cell death through a c-Fos-mediated and tumor cell specific signaling pathway. Brazilin has anti-inflammatory property, can suppress mastitis and high glucose-induced vascular inflammatory process related with the inhibition of oxidative stress, CAMs expression, and NF-κB activation in HUVEC; may be useful to treat chronic inflammatory disorders including rheumatoid arthritis.

Images & Validation

Key Properties

CAS Number474-07-7
MW286.28
Purity>98% (HPLC)
FormulaC16H14O5
SMILESC1C2=CC(=C(C=C2C3C1(COC4=C3C=CC(=C4)O)O)O)O
TargetAMPK
SolubilityIn Vitro: DMSO : 33.33 mg/mL (116.42 mM)

Bioactivity

In Vivo
Animal model: Chronic mild stress (CMS) mice model. Dosage: 10 mg/kg. Administration: Intraperitoneally injected (i.p.), once a day for 28 d. Result: Decreased the prolonged latency to feeding significantly.
In Vitro
Cell Viability Assay Cell line: PC12 cell line. Concentration: 10, 20 μM. Incubation time: 1 h. Result: Attenuated 200 μM H2O2-induced decrease in cell viability at the concentration of 10 μM and 20 μM. (47.83 and 91.51% of the control value, respectively)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Brazilin

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Brazilin (orb1222224)

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Available Sizes

Select a size below

200 mg
500 mg
5 mg
¥ 1,430.00
10 mg
¥ 1,950.00
25 mg
¥ 2,860.00
50 mg
¥ 4,030.00
100 mg
¥ 5,850.00