Cart summary

You have no items in your shopping cart.

Brigimadlin

SKU: orb1739557

Description

Brigimadlin (BI 907828) is a potent, orally bioavailable MDM2-p53 antagonist that disrupts the protein-protein interaction to reactivate p53 tumor suppressor function. It has demonstrated antitumor activity in preclinical research models, including studies of metastatic biliary tract cancer (BTC), pancreatic ductal adenocarcinoma (PDAC), lung adenocarcinoma, and bladder cancer, both in vitro and in vivo.

Research Area

Cell Biology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number2095116-40-6
MW591.46
Purity98.17%
FormulaC31H25Cl2FN4O3
SMILESC(N1[C@@]2([C@H]([C@]3([C@@]1(CC=4N3N=C5C4C=CC(C(O)=O)=C5C)[H])[H])C6=C(F)C(Cl)=CC=C6)C=7C(NC2=O)=CC(Cl)=CC7)C8CC8
TargetMdm2,MDM-2/p53,p53,E1/E2/E3 Enzyme

Bioactivity

In Vitro
Brigimadlin (at concentrations ranging from 0-10 nM; over 48 hours) inhibits the proliferation of BT48, BT50, BT67, BT69, BT89, and BT94, with respective IC50 values of 58.5, 21.1, 37.9, 89.8, 16.7, and 46.8 pM.

Storage & Handling

Storagekeep away from direct sunlight,store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Brigimadlin, BI 907828, BI907828, BI-907828, p53, MDM2, PSMA 1007, PSMA1007
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Brigimadlin (orb1739557)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 2,730.00
5 mg
¥ 4,290.00
1 ml x 10 mM (in DMSO)
¥ 5,460.00
10 mg
¥ 5,720.00
25 mg
¥ 8,970.00
50 mg
¥ 13,260.00
100 mg
¥ 19,500.00
DispatchUsually dispatched within 6-8 weeks
Bulk Enquiry