Brimonidine Tartrate

SKU: orb1224186

Description

Brimonidine Tartrate is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension.(In Vitro):[3H]Brimonidine (UK 14304) is a full agonist at alpha 2-adrenergic receptors. [3H]Brimonidine (UK 14304) labels at least 2 specific binding sites in human brain that both have the characteristics of an alpha 2-adrenergic binding site. GTP decreases agonist binding at both of these sites, but with different potencies at each site.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	70359-46-5
MW	442.22
Purity	>98% (HPLC)
Formula	C₁₅H₁₆BrN₅O₆
SMILES	C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
Target	Adrenergic Receptor
Solubility	Water: 75 mg/mL (169.59 mM); DMSO: 88 mg/mL (198.99 mM)

Bioactivity

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In Vitro	[3H]Brimonidine (UK 14304) is a full agonist at alpha 2-adrenergic receptors. [3H]Brimonidine (UK 14304) labels at least 2 specific binding sites in human brain that both have the characteristics of an alpha 2-adrenergic binding site. GTP decreases agonist binding at both of these sites, but with different potencies at each site [1-3].

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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AGN 190342LF | Alphagan P

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Quick Database Links

Gene Symbol

Adrenergic Receptor

Protocol Information

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Purity:	99.83% (May vary between batches)
CAS Number:	70359-46-5
MW:	442.22
Formula:	C₁₅H₁₆BrN₅O₆