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BT-13

SKU: orb1309897

Description

BT-13 is a small molecule RET agonist that functions independently of GDNF family ligands. It stimulates neurite outgrowth in sensory neurons in vitro and is used in research on neuroprotection, pain, and neurodegenerative disease models.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number924537-98-4
MW517.54
Purity98.41% (May vary between batches)
FormulaC23H27F4N3O4S
SMILESCCN(CC)S(=O)(=O)c1ccc(OC)c(c1)N1CCN(CC1)C(=O)c1ccc(F)cc1C(F)(F)F
TargetGDNF,c-RET
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.86 mM);DMSO:25 mg/mL (48.31 mM)

Bioactivity

In Vivo
In rats with surgery-induced neuropathy, BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons.
In Vitro
BT-13 stimulates phosphorylation of RET and RET-dependent intracellular signaling, but does not activate the BDNF receptor TrkB, the NGF receptor TrkA, or associated intracellular signaling in the absence of RET.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, GDNF receptor RET, inhibit, cRET, BT 13, BT13, BT-13, RET

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  • BT-13 [orb1217465]

    >98% (HPLC)

    924537-98-4

    517.54

    C23H27F4N3O4S

    5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 2 mg, 25 mg, 500 mg, 1 g
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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 mg
$ 80.00
2 mg
$ 100.00
5 mg
$ 130.00
1 ml x 10 mM (in DMSO)
$ 140.00
10 mg
$ 180.00
25 mg
$ 280.00
50 mg
$ 390.00
100 mg
$ 540.00
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