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BZAD01

SKU: orb1305364

Description

BZAD01 is a potent and selective antagonist of the NMDA receptor subtypes NR1A/2B. This small molecule is utilized in neuroscience research to investigate conditions like neuropathic pain and ischemic stroke, employing both in vitro binding assays and in vivo behavioral models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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BZAD01

Key Properties

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CAS Number305339-41-7
MW362.27
Purity99.51% (May vary between batches)
FormulaC16H12F6N2O
SMILESFC(F)(F)Oc1ccc(cc1)C(=N)NCc1ccccc1C(F)(F)F
TargetiGluR,NMDAR
SolubilityDMSO:55 mg/mL (151.82 mM)

Bioactivity

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In Vivo
Parkinsonism was induced by microinjection of the toxin, 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle (MFB) of 40 Sprague-Dawley rats. Parkinsonism and the efficacy of drugs were assessed using a battery of behavioural tests including balance beam, apomorphine-induced rotation, body axis bias or "curling", head position bias and disengage sensorimotor latency test. The main effects were that BZAD01 co-administration prevented chronic levodopa-induced potentiation of apomorphine rotation. However levodopa-treated rats were slower than either controls or BZAD-01-treated rats in the locomotor test.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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BZAD 01, BZAD01, BZAD-01, iGluR, Ionotropic glutamate receptors, NR2B, NR2B-NMDA, NR1A, inhibit, Inhibitor, NMDA
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
9863769 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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5 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 90.00
10 mg
$ 100.00
25 mg
$ 150.00
50 mg
$ 210.00
100 mg
$ 320.00
200 mg
$ 430.00
DispatchUsually dispatched within 3-5 working days
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