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BZAD01

SKU: orb1305364

Description

BZAD01 is a potent and selective antagonist of the NMDA receptor subtypes NR1A/2B. This small molecule is utilized in neuroscience research to investigate conditions like neuropathic pain and ischemic stroke, employing both in vitro binding assays and in vivo behavioral models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number305339-41-7
MW362.27
Purity99.78%
FormulaC16H12F6N2O
SMILESFC(F)(F)Oc1ccc(cc1)C(=N)NCc1ccccc1C(F)(F)F
TargetiGluR,NMDAR
SolubilityDMSO:55 mg/mL (151.82 mM)

Bioactivity

In Vivo
Parkinsonism was induced by microinjection of the toxin, 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle (MFB) of 40 Sprague-Dawley rats. Parkinsonism and the efficacy of drugs were assessed using a battery of behavioural tests including balance beam, apomorphine-induced rotation, body axis bias or "curling", head position bias and disengage sensorimotor latency test. The main effects were that BZAD01 co-administration prevented chronic levodopa-induced potentiation of apomorphine rotation. However levodopa-treated rats were slower than either controls or BZAD-01-treated rats in the locomotor test.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

BZAD 01, BZAD01, BZAD-01, iGluR, Ionotropic glutamate receptors, NR2B, NR2B-NMDA, NR1A, inhibit, Inhibitor, NMDA
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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

BZAD01 (orb1305364)

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Step 1: Enter information below

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Available Sizes

Select a size below

5 mg
¥ 1,040.00
1 ml x 10 mM (in DMSO)
¥ 1,170.00
10 mg
¥ 1,300.00
25 mg
¥ 1,950.00
50 mg
¥ 2,730.00
100 mg
¥ 4,160.00
200 mg
¥ 5,590.00
DispatchUsually dispatched within 3-5 working days
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