BzATP triethylammonium salt

SKU: orb1296342

Description

BzATP triethylammonium salt is a potent agonist for multiple P2X receptor subtypes (P2X1, P2X2, P2X3, P2X2/3, P2X4, P2X7). It is widely used in neuroscience and immunology research to study purinergic signaling, where it can induce cellular responses such as cell death and modulate synaptic transmission in both in vitro and in vivo models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	112898-15-4
MW	816.59
Purity	95.00% (May vary between batches)
Formula	C₃₀H₃₉N₆O₁₅P₃
SMILES	O[C@H]1[C@@H](O[C@@H]([C@H]1OC(C2=CC=C(C=C2)C(C3=CC=CC=C3)=O)=O)COP(OP(OP(O)(O)=O)(O)=O)(O)=O)N4C=NC5=C4N=CN=C5N.CCN(CC)CC
Target	P2X Receptor
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.45 mM);DMSO:50 mg/mL (61.23 mM);H2O:50 mg/mL (61.23 mM)

Bioactivity

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Target IC50	P2X1:8.74 (pEC50)\|P2X7 (Rat):3.6 μM\|P2X3:7.1 (pEC50)\|P2X4:6.31 (pEC50)\|P2X2:5.26 (pEC50)
In Vivo	METHODS: To investigate the effects on whole-body energy metabolism, BzATP triethylammonium salt (1 mg/kg) was administered intraperitoneally to C57BL/6J mice once daily for seven days. RESULTS: BzATP triethylammonium salt increased metabolic rate and O2 consumption while decreasing respiratory rate and upregulating NADPH oxidase 2 in gastrocnemius and tibialis anterior muscle.The findings suggest that activation of P2X7 has a significant effect on energy homeostasis and muscle metabolism.
In Vitro	METHODS: Glioma cell lines U87 and U251 were treated with BzATP triethylammonium salt (5-1000 µM) for 2-72 h. Cell proliferation was detected by MTT assay. RESULTS: Proliferation of glioma cell lines U87 and U251 was significantly increased in the presence of BzATP. the peak fine cell proliferation of both U87 and U251 cell lines was 100 µM BzATP, and the optimal incubation time was 24 h for both cell lines . METHODS: Retinal ganglion cells were treated with BzATP triethylammonium salt (50 µM) for 2 min and intracellular Ca2+ levels were measured. RESULTS: The P2X7 agonist BzATP resulted in a rapid increase in intracellular Ca2+ and the level remained elevated for 2 min after agonist application. More than 80% of the examined cells responded strongly to BzATP.

Storage & Handling

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Storage	store at low temperature,keep away from moisture,store under nitrogen \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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BzATP triethylammonium, BzATP triethylammonium salt, P2X7, P2XReceptor, P2X Receptor

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BzBzATP (BzATP) [orb65285]

Purity:	≥ 95% (HPLC)
CAS Number:	112898-15-4
MW:	Theoretical MW: 1018.97 g/mol [tri(triethylammonium salt)]; 715.40 g/mol (free acid); Detected MW: 715.05 g/mol (free acid)
Formula:	C₂₄H₂₄N₅O₁₅P₃ * 3 (C₆H₁₅N); C 24H₂₄N₅O₁₅P₃

Sizes Available: 25 mg

Item 1 of 1
BzATP [orb1713804]
Purity:
>97.7%
CAS Number:
112898-15-4
MW:
1018.97
Formula:
C₂₄H₂₄N₅O₁₅P₃•C₁₈H₄₅N₃
Sizes Available: 5 mg, 25 mg

BzBzATP (BzATP) [orb1734022]

Purity:	≥ 95% (HPLC)
CAS Number:	112898-15-4
MW:	Theoretical MW: 1018.97 g/mol [tri(triethylammonium salt)]; 715.40 g/mol (free acid); Detected MW: 715.05 g/mol (free acid)
Formula:	C₂₄H₂₄N₅O₁₅P₃ * 3 (C₆H₁₅N); C 24H₂₄N₅O₁₅P₃

Sizes Available: 5 mg

BzATP triethylammonium salt [orb1219089]
Purity:
>98% (HPLC)
CAS Number:
112898-15-4
MW:
1018.96
Formula:
C₂₄H₂₄N₅O₁₅P₃·C₁₈H₄₅N₃
Sizes Available: 10 mg, 1 g, 500 mg, 200 mg, 100 mg, 5 mg

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Compound Identifiers

PubChem CID

156598998 ↗

Key Properties

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No computed properties available.

Protocol Information

Find More Protocols

Purity:	>97.7%
CAS Number:	112898-15-4
MW:	1018.97
Formula:	C₂₄H₂₄N₅O₁₅P₃•C₁₈H₄₅N₃

Purity:	>98% (HPLC)
CAS Number:	112898-15-4
MW:	1018.96
Formula:	C₂₄H₂₄N₅O₁₅P₃·C₁₈H₄₅N₃

BzATP triethylammonium salt

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

BzBzATP (BzATP) [orb65285]

BzATP [orb1713804]

BzBzATP (BzATP) [orb1734022]