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Carmofur

SKU: orb1309038

Description

Carmofur (HCFU) is a potent acid ceramidase inhibitor investigated for breast and colorectal cancer. Research applications include in vitro studies of ceramide metabolism and in vivo models exploring its antitumor effects and associated leukoencephalopathy.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Carmofur

Key Properties

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CAS Number61422-45-5
MW257.26
Purity98.59% (May vary between batches)
FormulaC11H16FN3O3
SMILESCCCCCCNC(=O)n1cc(F)c(=O)[nH]c1=O
TargetNucleoside Antimetabolite/Analog|||Virus Protease|||DNA/RNA Synthesis|||SARS-CoV
SolubilityDMSO:250 mg/mL (971.78 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:10 mg/mL (38.87 mM)

Bioactivity

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Target IC50
AC:29 ± 5 nM
In Vitro
Carmofur is one of the masked compounds of 5-FU, which was modified for more potent antineoplastic activity and less toxicity. Carmofur is converted in vivo into 5-FU directly or via intermetabolites, such as 1-(carboxypentylcarbamoyl)-5-fluorouracil and/or 1-(carboxypropylcarbomoyl)-5-fluorouraci. Carmofur and its metabolites gradually accumulate in the brain during continuous administration and are removed very slowly. Carmofur has potent neurotoxicity which can produce severe leucoencephalopathy resembling methotrexate leucoencephalopathy both clinically and on brain CT, together with a cerebellar syndrome similar to that following 5-FU neurotoxicity.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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derivative, DNA/RNA Synthesis, DNA Synthesis, DNASynthesis, Analog, antineoplastic, Carmofur, 5-fluorouracil, inhibit, Mpro, Nucleoside Antimetabolite/Analog, NucleosideAntimetabolite, Nucleoside Antimetabolite, HCFU, Inhibitor, VirusProtease, Virus Protease, protease, RNASynthesis, RNA Synthesis, SARSCoV, SARS-CoV, SARS coronavirus

Similar Products

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  • Carmofur [orb1224457]

    >98% (HPLC)

    61422-45-5

    257.27

    C11H16FN3O3

    50 mg, 100 mg, 200 mg, 500 mg, 1 g
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
2577 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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1 ml x 10 mM (in DMSO)
$ 70.00
50 mg
$ 80.00
100 mg
$ 90.00
200 mg
$ 100.00
DispatchUsually dispatched within 3-5 working days
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