Carotuximab Antibody

SKU: orb1980503

Description

Carotuximab (DE-122) is a CD105-targeting antibody that inhibits Smad signaling, exerting potent antiangiogenic and immunomodulatory effects. It is utilized in oncology and vascular biology research to study endothelial dysfunction in models of hypercholesterolemia and hyperglycemia, both in vitro and in vivo.

Research Area

Immunology & Inflammation, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	1268714-50-6
MW	144.8 kDa
Purity	SDS-PAGE:95% SEC-HPLC:95%
Target	Immunology/Inflammation related,TGF-beta/Smad

Bioactivity

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In Vivo

In acute myeloid leukemia (AML) xenografts, the combination of Carotuximab (TRC105) and Decitabine, administered intravenously at a dose of 2 mg/kg once every 3 days for 8 weeks, produces a more durable anti-leukemia effect. Additionally, this combination enhances reactive oxygen species (ROS) activity .

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Carotuximab, CD105, DE122, DE-122, DE 122, Immunology related, Immunologyrelated, Inflammation related, Inflammationrelated, Smad, TGFb, TGF-b/Smad, TGFβ, TGF-β/Smad, TGF-beta, TGFbeta, TGF-beta/Smad, TGFbeta/Smad, TRC 105, TRC105, TRC-105

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Gene Symbol

Immunology/Inflammation related,TGF-beta/Smad

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