CASP10 (M) Antibody, Rabbit Polyclonal

SKU: orb66964

Description

Rabbit polyclonal to CASP10.Caspase 10 (CASP10) belongs to the peptidase C14A family, which is involved in the activationcascade of caspases responsible for apoptosis execution. CASP10 is recruited to both Fas-andTNFR-1 receptors in a FADD dependent manner, and may participate in the granzyme B apoptoticpathways. CASP10 cleaves and activates caspase-3, -4, -6, -7, -8, and -9, and hydrolyzes the smallmoleculesubstrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Defects in CASP10 havebeen implicated in autoimmune lymphoproliferative syndrome type 2A (ALPS2A), familial non-Hodgkin lymphoma (NHL) and gastric cancer (GASC).

Research Area

Apoptotic, Cancer, Epigenetics, Neuroscience, Signaling Pathways

Images & Validation

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Tested Applications	WB
Dilution range	WB:1:1000-1:5000
Reactivity	Human

Key Properties

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Host	Rabbit
Clonality	Polyclonal
Immunogen	middle region of human CASP10
Molecular Weight	59
Purity	Affinity purification
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.01% NaN3
Disclaimer	For research use only

Alternative Names

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anti-CASP10 antibody,anti-Caspase10 antibody,anti-CASP10 antibody,anti-Apoptotic protease Mch4 antibody,anti-MCH4 antibody,anti-FASassociated death domain protein interleukin1Bconverting enzyme 2 antibody,anti-FLICE2 antibody,anti-ICElike apoptotic protease 4 antibody

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Western blot analysis of total cell extracts from human Hela using CASP10 antibody

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UniProt

Q92851

UniProt Details

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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