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Catechin

SKU: orb1310261

Description

Catechin

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience

Images & Validation

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Catechin

Key Properties

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CAS Number154-23-4
MW290.27
Purity97.34% (May vary between batches)
FormulaC15H14O6
SMILESO[C@@H]1[C@H](OC=2C(C1)=C(O)C=C(O)C2)C3=CC(O)=C(O)C=C3
TargetInfluenza Virus,Apoptosis,Endogenous Metabolite,COX
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (17.23 mM);DMSO:260 mg/mL (895.72 mM);H2O:25 mg/mL (86.13 mM);Ethanol:54 mg/mL (186.03 mM)

Bioactivity

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Target IC50
COX-2:130 μM|COX-1:80 μM
In Vivo
Dietary catechin significantly delayed tumor onset. Continued intake of catechin, a potential antioxidant, prevents memory regression and DNA oxidative damage in senescence-accelerated (SAMP10) mice. It does not prolong the lifetime of SAMP10 mice, but it does delay brain senescence. (+)-Catechin inhibits intestinal tumor formation and suppresses Focal adhesion kinase activation in the Min/+ Mouse.
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In Vitro
The catechin flavonoid reduces proliferation and induces apoptosis of murine lymphoma cells LB02 through modulation of antiapoptotic proteins. Treatment of human prostate cancer cells with catechin induces apoptosis and results in effects on a variety of survival signals suggesting the potential of these compounds as chemopreventive agents for prostate cancer. Catechin is well known to inhibit cyclooxygenase activity with reported IC50 values ranging from 4O μM to 943 μM. It has also been reported to act as an inhibitor of COX-1 and COX-2 with IC50 of about 80 μM and 130 μM.
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Cell Research
LB02 cells were resuspended in RPMI 10% FBS in a concentration of 5x105 cells/mL. The cultures were performed in 96-well round-bottomed microtitre plates in presence of different concentrations of catechin or rutin (10, 50, 100 or 200 μg/mL). After 48 h at 37 ºC in a humidified atmosphere with 5% CO2 in the air, cultures were pulsed with 1 μCi of 3H-thymidine/well and maintained for an additional 18 h period prior to a semiautomatic method harvest. (Only for Reference)
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Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Endogenous Metabolite, EndogenousMetabolite, D-Catechin, COX, COX-1, COX-2, Cianidanol, Apoptosis, Catechuic acid, Catechin, Catechinic acid, (+)-Catechin, Influenza Virus, InfluenzaVirus

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  • (±)-Catechin

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
9064 ↗

Key Properties

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No computed properties available.

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Catechin (orb1310261)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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25 mg
¥ 910.00
1 ml x 10 mM (in DMSO)
¥ 1,040.00
50 mg
¥ 1,040.00
100 mg
¥ 1,170.00
500 mg
¥ 2,210.00
1 g
¥ 2,990.00
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