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CAY10526

SKU: orb1305555

Description

CAY10526 (BTH) is a selective microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor that suppresses the NF-κB signaling pathway. It is a valuable research tool for studying inflammation, pain, and cancer in both cellular and animal models, as evidenced by published in vitro and in vivo studies.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number938069-71-7
MW311.15
Purity98.75% (May vary between batches)
FormulaC12H7BrO3S
SMILESOC1OC(=O)C(Br)=C1c1cc2ccccc2s1
TargetPGE Synthase,Prostaglandin Receptor
SolubilityEthanol:1 mg/mL (3.21 mM);10% DMSO+90% Saline:1.5 mg/mL (4.82 mM);DMF:16 mg/mL (51.42 mM);DMSO:16 mg/mL (51.42 mM)

Bioactivity

Target IC50
mPGES-1:1.8 μM
In Vitro
CAY10526 dose-dependently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells with an IC50 value of 1.8 μM without any effect on COX-2 expression.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

cleaved caspase 3, CAY10526, CAY-10526, A375, BTH, CAY 10526, anti-apoptotic, microsomal PGE2 synthase-1, inhibit, increases apoptosis, increases BAX and BAK, mPGES1 inhibitor, mPGES-1, Inhibitor, melanoma xenografts, SB2, Prostaglandin Receptor, Prostaglandin E synthase, ProstaglandinReceptor, pro-apoptotic, PGE2 production, PGE synthase, WM793
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Key Properties

No computed properties available.

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Protocol Information

CAY10526 (orb1305555)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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1 mg
¥ 1,300.00
5 mg
¥ 2,340.00
1 ml x 10 mM (in DMSO)
¥ 2,600.00
10 mg
¥ 3,510.00
25 mg
¥ 6,370.00
DispatchUsually dispatched within 3-5 working days
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