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CCT 137690

SKU: orb1305267

Description

CCT 137690 is a potent and orally bioavailable small molecule inhibitor targeting Aurora kinases A, B, and C with IC50 values of 15, 25, and 19 nM, respectively. It is a valuable research tool for studying mitotic regulation and has demonstrated anti-proliferative activity in various cancer cell lines in vitro.

Research Area

Cell Biology, Epigenetics & Chromatin

Images & Validation

Key Properties

CAS Number1095382-05-0
MW551.48
Purity>99.99% (May vary between batches)
FormulaC26H31BrN8O
SMILESCN1CCN(CC1)c1ccc(cc1)-c1nc2c(N3CCN(Cc4cc(C)on4)CC3)c(Br)cnc2[nH]1
TargetApoptosis,Aurora Kinase
SolubilityDMSO:55.2 mg/mL (100.09 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.81 mM)

Bioactivity

Target IC50
Aurora A:15 nM|Aurora B:25 nM|Aurora C:19 nM
In Vivo
CCT137690 acts as an inhibitor of the hERG ion channels (IC50=3.0 μM) and effectively suppresses cell growth across various human tumor cell lines from different organs. It exhibits potent inhibitory effects on SW620 colon cancer cells (GI50=0.3 μM) and A2780 ovarian cancer cells (GI50=0.14 μM).
In Vitro
In transgenic mouse models of neuroblastoma, CCT137690 significantly inhibits tumor cell growth. Similarly, in SW620 colon carcinoma xenograft models, oral administration of CCT137690 can suppress cell growth.
Cell Research
The effects of CCT137690 on cell proliferation are analyzed with the colorimetric 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cells such as SW620 and A2780 are plated in 96-well plates at 2.5 × 103 per well and are treated with a range of 0 to 50 μM of CCT137690 for 72 hours. The absorbance is measured at 570 nm using the Wallac VICTOR2TM 1420 Multilabel Counter.(Only for Reference)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Aurora B, Aurora Kinase, Aurora C, AuroraKinase, Aurora A, Apoptosis, CCT137690, CCT-137690, CCT 137690, inhibit, Inhibitor

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  • CCT 137690 [orb1226996]

    >98% (HPLC)

    1095382-05-0

    551.4813

    C26H31BrN8O

    1 g, 500 mg, 200 mg, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
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Key Properties

No computed properties available.

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Protocol Information

CCT 137690 (orb1305267)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,040.00
5 mg
¥ 1,560.00
1 ml x 10 mM (in DMSO)
¥ 1,690.00
10 mg
¥ 1,820.00
25 mg
¥ 2,990.00
50 mg
¥ 4,810.00
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