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CD73-IN-3

SKU: orb1298561

Description

CD73-IN-3 (LY-3475070) is a potent and selective CD73 inhibitor with an IC50 of 28 nM. It is utilized in immuno-oncology research to study adenosine-mediated immunosuppression in tumor microenvironments, both in vitro and in preclinical in vivo models, often in combination with immune checkpoint inhibitors.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number2375815-63-5
MW286.33
Purity99.76% (May vary between batches)
FormulaC15H18N4O2
SMILES[H][C@@]1(C[C@@H]1C(C)C)c1cc(nnc1C)-c1c[nH]c(=O)[nH]c1=O
TargetCD73
SolubilityDMSO:22.5 mg/mL (78.58 mM)

Bioactivity

Target IC50
CD73:28 nM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

cancer, CD73, CD73 IN 3, CD73IN3, CD-73-IN-3, CD73-IN-3, EX-A4254, EX-A-4254, EX-A 4254, inhibit, Inhibitor, Immunosuppression, LY 3475070, LY3475070, LY-3475070, tumor
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

CD73-IN-3 (orb1298561)

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Available Sizes

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1 mg
¥ 1,300.00
5 mg
¥ 2,470.00
1 ml x 10 mM (in DMSO)
¥ 2,730.00
10 mg
¥ 3,640.00
25 mg
¥ 5,720.00
50 mg
¥ 7,930.00
100 mg
¥ 10,530.00
200 mg
¥ 13,390.00
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