CD8β recAb (YTS156.7.7), InvivoPure+

SKU: orb3127243

Description

The CD8β recAb (YTS156.7.7) reacts with the ~25 kDa beta subunit of mouse CD8αβ, also known as Ly-3, Lyt-3, CD8β or CD8 beta subunit. CD8αβ acts as a co-receptor with peptide- bound class I major histocompatibility complex (pMHC) on antigen-presenting cells (APC) for TCR-mediated activation of cytotoxic T cells. CD8β recAb (YTS156.7.7) blocks this interaction, playing an essential role in immune responses against internal and external offenses. The CD8β mAb (YTS156.7.7) is widely used as a phenotypic marker for mouse CD8αβ on cytotoxic T cells. The original CD8β antibody (clone YTS156.7.7) is of rat IgG2b isotype. The present CD8β recAB (YTS156.7.7) antibody is designed as a chimeric antibody with wildtype mouse IgG2a kappa isotype, resulting in an anti-mouse CD8β recAb (YTS156.7.7) mouse IgG2a recombinant antibody.

Images & Validation

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Reactivity	Mouse
Application Notes	Recomended Isotype: Mouse IgG2A k Isotype Control. Recomended Isotype Catalog: orb2568793

Key Properties

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Antibody Type	Recombinant Antibody
Clonality	Monoclonal
Isotype	m IgG2a k
Clone No.	YTS156.7.7
Immunogen	Mouse CD8 (lyt-3)
Target	CD8b, Ly-3, Lyt-3
Purity	≥ 95 % (CGE, reducing conditions) ≤ 10 % aggregates (analytical SEC) Endotoxin level ≤ 1 EU/mg
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Form/Appearance	Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
Concentration	≥ 1 mg/ mL
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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anti CD8 beta, anti-mouse CD8 beta, T-cell surface glycoprotein CD8 beta chain, anti-CD8b, monoclonal CD8b, Cd8b, CD8b1, Ly-3, Lyt-3, Lyt3, Lymphocyte antigen 3, T-cell membrane glycoprotein Ly-3, T-cell surface glycoprotein Lyt-3, recombinant monoclona CD8b.

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Quick Database Links

Gene Symbol

CD8b, Ly-3, Lyt-3

UniProt

P10300

UniProt Details

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No UniProt data available

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