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CDKI-73

SKU: orb1308471

Description

CDKI-73 is a highly potent and selective CDK9 inhibitor (Ki = 4 nM) with significant toxicity toward chronic lymphocytic leukemia (CLL) cells in vitro. Its mechanism involves inducing apoptosis and synergizing with chemotherapeutics like cisplatin, highlighting its research utility in oncology and hematology for studying transcription-dependent cancers.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number1421693-22-2
MW394.45
Purity98.11% (May vary between batches)
FormulaC15H15FN6O2S2
SMILESCNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1F
TargetApoptosis,CDK
SolubilityDMSO:52 mg/mL (131.83 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (6.34 mM)

Bioactivity

Target IC50
CDK9:5.78 nM|CDK2:3.27 nM|CDK4:8.18 nM|CDK1:8.17 nM|CDK7:134.26 nM|CDK6:37.68 nM
In Vivo
CDKI-73 exhibited a favorable pharmacokinetic profile with oral bioavailability of F = 56% following a single intravenous bolus dose at 2 mg/kg and an oral dose at 10 mg/kg in mice .
In Vitro
CDKI-73, one of the most potent CDK9 inhibitors, against a panel of AML cell lines and samples derived from 97 patients. CDKI-73 induced cancer cells undergoing apoptosis through transcriptional downregulation of anti-apoptotic proteins Bcl-2, Mcl-1 and XIAP by majorly targeting CDK9.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CDK9, CDKI 73, CDKI73, CDKI-73, CDK7, CDK6, CDK4, CDK2, CLL, CDK1, CDK, Cyclin dependent kinase, AML, Apoptosis, Acute, inhibit, Inhibitor, LS007, LS-007, LS 007, low, myeloid, endosome, leukemia, toxicity
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Key Properties

No computed properties available.

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CDKI-73 (orb1308471)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 2,470.00
2 mg
¥ 3,120.00
5 mg
¥ 4,550.00
1 ml x 10 mM (in DMSO)
¥ 4,810.00
10 mg
¥ 6,370.00
25 mg
¥ 10,140.00
50 mg
¥ 13,390.00
100 mg
¥ 18,590.00
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