Cendakimab Antibody

SKU: orb1980502

Description

Cendakimab (RPC4046) is a humanized monoclonal antibody designed to selectively inhibit interleukin-13 (IL-13) by targeting its receptors, IL13R-α1 and IL13R-α2. It is utilized in preclinical research, including in vitro and in vivo studies, for investigating pathways in atopic dermatitis and related allergic diseases.

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	2151032-62-9
MW	146.44 kDa
Purity	96% (SEC-HPLC)
Target	Interleukin

Bioactivity

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Target IC50	IL-13Rα1:352 pM\|glycosylated IL-13:37 pM\|IL-13α2:631 pM\|aglycosylated IL-13:17 pM
In Vivo	In a mouse model of asthma, Cendakimab dose-dependent inhibited AHR (maximum inhibition 70.5%) and IL-13-dependent gene expression, and maximal inhibition of Muc5ac and AMCase activity was 70.7% and 54.2%, respectively. Read more...
In Vitro	Cendakimab is an IgG1k humanized monoclonal antibody that recognizes IL-13 and inhibits its binding to IL-13 receptor-specific subtypes (IL-13-Rα1 and IL-13-Rα2) with an IC50 of 352 pM and 631 pM, respectively, as determined by ELISA. cendakimab inhibited glycosylated and non-glycosylated IL-13-induced STAT6 activity in a dose-dependent manner with IC50 of 37pM and 17pM, respectively. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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RPC4046, RPC 4046, ABT308, ABT-308, CC93538, CC 93538

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Gene Symbol

Interleukin

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