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Cenerimod

SKU: orb1707473

Description

Cenerimod (ACT-334441) is a potent and selective oral S1P1 receptor agonist with an EC50 of 1 nM. It is utilized in preclinical research to investigate autoimmune conditions, including studies in murine models of experimental autoimmune encephalomyelitis (EAE) and scleroderma.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1262414-04-9
MW453.53
Purity99.97%
FormulaC25H31N3O5
SMILESCCc1cc(cc(C)c1OC[C@@H](O)CO)-c1noc(n1)-c1cc(OC)nc(c1)C1CCCC1
TargetS1P Receptor,LPL Receptor
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.28 mM);DMSO:80 mg/mL (176.39 mM)

Bioactivity

Target IC50
S1P1 receptor:1 nM (EC50)|S1P4 receptor:2134 nM (EC50)|S1P5 receptor:228 nM (EC50)|S1P5 receptor:36 nM (EC50)
In Vivo
In male Wistar rats weighing 294-510 g, Cenerimod (0.1, 0.3, 1, 3, and 10 mg/kg; single oral dose) effectively and reversibly reduced blood lymphocyte counts.
In Vitro
Cultured fibroblasts were pretreated with a vehicle or Cenerimod (5 μmol/L), followed by incubation with TGF-β2 (10 ng/mL) for 24 hours. The results indicated that Cenerimod inhibited collagen production in fibroblasts.

Storage & Handling

Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Cenerimod, ACT334441, ACT-334441, ACT 334441, S1PReceptor, S1P Receptor, S1P1
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Cenerimod (orb1707473)

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% Tween 80 +
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Available Sizes

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2 mg
¥ 1,040.00
5 mg
¥ 1,300.00
1 ml x 10 mM (in DMSO)
¥ 1,430.00
10 mg
¥ 1,820.00
25 mg
¥ 2,600.00
50 mg
¥ 3,510.00
DispatchUsually dispatched within 5-10 working days
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