Chalcone

SKU: orb1221956

Description

trans-Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.

Images & Validation

−

Key Properties

−

CAS Number	614-47-1
MW	208.26
Purity	>98% (HPLC)
Formula	C₁₅H₁₂O
SMILES	c1ccc(cc1)/C=C/C(=O)c1ccccc1
Target	p53
Solubility	In Vitro: DMSO : 100 mg/mL (480.17 mM)

Bioactivity

−

In Vitro

trans-Chalcone competitively inhibits porcine pancreatic α-amylase with a Ki of 48 μM. trans-Chalcone (30.23-98.03 μM; 24 hours) induces cell cycle arrest and apoptosis in MCF-7 cells. trans-Chalcone (20-80 μM; 24, 48 hours) reduces the expression of the apoptosis-related protein Bcl-2. trans-Chalcone (58.25 μM; 6, 24 hours) has greater inhibition of Bcl-2, induction of APAF1 and BAX, and strong induction of CIDEA in 24 hours. trans-Chalcone (24 hours) inhibits MCF-7 cell viability (IC20 = 30.23 μM; IC50 = 58.25 μM; IC80 = 98.03 μM). trans-Chalcone (48 h) has IC50s of 41.53 μM and 48.41 μM for MCF-7 and 3T3 cell lines, respectively. trans-Chalcone exhibits a pronounced cytotoxicity activity. Apoptosis Analysis Cell line: MCF-7 cell. Concentration: 30.23, 58.25, 98.03 μM Incubation time: 24 hours. Result: Induced apoptosis of the breast cancer cell line. Cell Cycle Analysis Cell line: MCF-7 cell. Concentration: 30.23, 58.25, 98.03 μM Incubation time: 24 hours. Result: Caused cell cycle arrest in G1. Western blot analysis. Cell line: MCF-7 cell. Concentration: 20, 40, 80 μM. Incubation time: 24, 48 hours. Result: Reduced the expression of the apoptosis-related protein Bcl-2 and induced the expression of the CIDEA gene. There was marked degradation of cyclin D1 at 48 h. RT-PCR Cell line: MCF-7 cell. Concentration: 58.25 μM Incubation time: 6, 24 hours. Result: Had greater inhibition of Bcl-2, induction of APAF1 and BAX, and strong induction of CIDEA in 24 hours.

Storage & Handling

−

Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Quick Database Links

Gene Symbol

p53

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

Chalcone (orb1221956)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

Applications:	ELISA, WB
Reactivity:	Plant
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	ELISA, WB
Reactivity:	Plant
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	ELISA, WB
Reactivity:	Plant
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	ELISA, WB
Reactivity:	Plant
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	ELISA, WB
Reactivity:	A. thaliana
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Chalcone

Description

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Similar Products

CHI Antibody [orb837006]

WHP1 Antibody [orb837354]

CHI Antibody [orb837360]

C2 Antibody [orb837362]

CHI2 Antibody [orb785679]

Quality Guarantee

Quick Database Links

Documents Download

Request a Document

Protocol Information

Chalcone (orb1221956)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors