Cholesteryl Hemisuccinate

SKU: orb1745228

Description

Cholesteryl Hemisuccinate is a water-soluble cholesterol derivative with hepatoprotective and anticancer properties. It is used in research to study mechanisms against drug-induced liver injury (e.g., acetaminophen) and to investigate inhibition of DNA polymerases and topoisomerases in vitro, impacting cell replication and repair pathways.

Research Area

Cell Biology, Molecular Biology

Images & Validation

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Key Properties

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CAS Number	1510-21-0
MW	486.73
Purity	99.98% (May vary between batches)
Formula	C₃₁H₅₀O₄
SMILES	[H][C@@]12CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@H](CC[C@]12C)OC(=O)CCC(O)=O
Target	Topoisomerase,Necroptosis,Apoptosis,DNA/RNA Synthesis
Solubility	10% EtOH+90% Corn Oil:2 mg/mL (4.11 mM);Ethanol:22.5 mg/mL (46.23 mM);DMSO:10 mg/mL (20.55 mM)

Bioactivity

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In Vivo	Cholesteryl Hemisuccinate (100 mg/kg ; ip ; single administration before AAP) eliminated AAP-induced apoptosis and necrosis in ICR mice (CD-1) for histological and biochemical diagnosis. Read more...
In Vitro	Cholesteryl Hemisuccinate (0-1000 μM) inhibited the growth of MCF-7 and MCF-10A cells.

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Cholesterol hydrogen succinate, Cholesterol hydrogen Succinate, Cholesteryl, Cholesteryl Hemisuccinate, DNA polymerase, DNA Synthesis, DNASynthesis, Apoptosis, Topo, RNA Synthesis, RNASynthesis

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Compound Identifiers

PubChem CID

65082 ↗

Key Properties

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No computed properties available.

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