Cart summary

You have no items in your shopping cart.

Chrysosplenol D

SKU: orb1297425

Description

Chrysosplenol D is a natural flavonoid efflux pump inhibitor that restores susceptibility to antibiotics and antimalarials in resistant strains. Its ability to potentiate drug efficacy has been demonstrated in vitro against pathogens like Staphylococcus aureus and Plasmodium falciparum, supporting research in antimicrobial resistance and infectious disease.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Images & Validation

Key Properties

CAS Number14965-20-9
MW360.31
Purity99.98%
FormulaC18H16O8
SMILESCOc1cc2oc(-c3ccc(O)c(O)c3)c(OC)c(=O)c2c(O)c1OC
TargetApoptosis,JNK,IL Receptor,NF-κB
SolubilityDMSO:55 mg/mL (152.65 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.55 mM)

Bioactivity

Target IC50
Viability:11.6 µM(MDA-MB-231 TNBC cells)
In Vitro
Trace amounts of the antimalarial sesquiterpene lactone artemisinin may account for the activity of the n-hexane fraction but only the methoxylated flavonoids artemetin, chrysoplenetin, chrysosplenol-D and cirsilineol can account for the activity of the chloroform extract. These purified flavonoids were found to have IC50 values at 2.4 - 6.5 x 10(-5)M against P. falciparum in vitro compared with an IC50 value of about 3 x 10(-8)M for purified artimisinin

Storage & Handling

Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

breast, Chrysosplenol D, cancer, anti-inflammatory, Apoptosis, antitrypanosomal, NFkB, NF-kB, NF-κB, NFκB, ILReceptor, inhibit, JNK, ERK1/2, IL Receptor, Inhibitor
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Chrysosplenol D (orb1297425)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,690.00
5 mg
¥ 3,120.00
1 ml x 10 mM (in DMSO)
¥ 3,380.00
10 mg
¥ 4,810.00
25 mg
¥ 7,540.00
50 mg
¥ 10,530.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry