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Cilofexor

SKU: orb1299821

Description

Cilofexor is a potent and selective farnesoid X receptor (FXR) agonist. It functions by binding to and activating FXR, thereby inhibiting the interaction with synthetic peptide ligands. This small molecule is utilized in research on metabolic and liver diseases, including in vitro assays and in vivo models of cholestasis and NASH.

Research Area

Cell Biology, Metabolism Research

Images & Validation

Key Properties

CAS Number1418274-28-8
MW586.85
Purity98.00% (May vary between batches)
FormulaC28H22Cl3N3O5
SMILESOC(=O)c1ccnc(c1)N1CC(O)(C1)c1ccc(OCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)cc1Cl
TargetAutophagy|||FXR
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.82 mM);DMSO:125 mg/mL (213 mM)

Bioactivity

Target IC50
FXR:43 nM (EC50)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

antifibrotic, anti-inflammatory, Autophagy, Cilofexor, GS9674, GS-9674, GS 9674, FXR, inhibit, Inhibitor, NR1H4, nonsteroidal, oral, NASH, safety, PSC

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 90.00
2 mg
$ 110.00
5 mg
$ 170.00
1 ml x 10 mM (in DMSO)
$ 210.00
10 mg
$ 240.00
25 mg
$ 440.00
50 mg
$ 640.00
100 mg
$ 830.00
500 mg
$ 1,830.00
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