Cinepazide maleate

SKU: orb1310683

Description

Cinepazide maleate

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	26328-04-1
MW	533.57
Purity	99.97%
Formula	C₂₂H₃₁N₃O₅·C₄H₄O₄
SMILES	OC(=O)\C=C/C(O)=O.COc1cc(\C=C\C(=O)N2CCN(CC(=O)N3CCCC3)CC2)cc(OC)c1OC
Target	Calcium Channel

Bioactivity

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In Vitro

Cinepazide exhibits strong chronotropic and inotropic effects. Intravenous administration of Cinepazide (1 mg/kg - 3 mg/kg) leads to an 8% increase in heart rate while reducing blood pressure by 4%. Cinepazide selectively enhances the functional activity of 5-HT neurons in the brain, although hypoxia inhibits its activity. Doses of Cinepazide (3 mg/kg - 30 mg/kg) administered intravenously transiently increase renal and femoral arterial blood flow, spinal and carotid blood flow, and cardiac output in anesthetized dogs while decreasing total peripheral resistance, exhibiting a concentration-dependent relationship with these effects. At 30 mg/kg, Cinepazide enhances the dilatory neural response of dog spinal blood vessels to intrathecal adenosine and adenylic acid. Cinepazide (1 mg - 10 mg) amplifies blood flow within spinal vessels in a dose-dependent manner, partially inhibited by pretreatment with intravenous aminophylline and unaffected by autonomic antagonists. Cinepazide is well absorbed, with over 60% excreted within 24 hours. Over five days, the excretion of Cinepazide through feces and urine is 58.3% and 36.7% in rats, 68.6% and 33.4% in dogs, and 38.1% and 61.3% in humans, respectively.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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piperazine derivative, stroke, Vasodistal, vasodilator, brain?infarct, Calcium Channel, CalciumChannel, Ca2+ channels, Ca channels, Cinepazide Maleate, Cinepazide maleate, Cinepazide, Brendil, cerebrovascular disease, inhibit, Inhibitor, ischemic, MD 67350, MD67350, MD-67350

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Compound Identifiers

PubChem CID

5282458 ↗

Key Properties

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No computed properties available.

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