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cis-EpS

SKU: orb1737573

Description

cis-Epoxysuccinic acid is a dual-function small molecule, acting as a potential agonist for SUCNR1 (Succinate Receptor 1) and an inhibitor of ICL1 (Isocitrate Lyase 1). It is used in biochemical research to study metabolic signaling pathways and microbial persistence, with applications in both in vitro enzyme assays and cellular receptor studies.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number16533-72-5
MW132.07
Purity99.81%
FormulaC4H4O5
SMILESC(O)(=O)[C@H]1[C@@H](C(O)=O)O1
TargetOthers,Succinate Receptor 1 (SUCNR1)
SolubilityDMSO:200 mg/mL (1514.35 mM)

Bioactivity

Target IC50
SUCNR1:2.7 μM (EC₅₀)
In Vivo
In vivo, cis-Epoxysuccinic acid significantly increases blood pressure in rats via SUCNR1 activation, demonstrating comparable potency to succinic acid.
In Vitro
In vitro, cis-Epoxysuccinic acid acts as a potent agonist of the succinate receptor (SUCNR1), with enhanced efficacy across several assays (e.g., cAMP inhibition, calcium mobilization, TGF-α shedding, and β-arrestin-3 recruitment). Cis-Epoxysuccinic acid suppresses cAMP levels with an EC₅₀ of 2.7 μM (pEC₅₀ = 5.57), making Cis-Epoxysuccinic acid approximately 10–20 times more potent than succinic acid.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

cis-Epoxysuccinic acid, cis-2,3-Oxiranedicarboxylic Acid, PLX-7683, PLX 7683.
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Key Properties

No computed properties available.

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cis-EpS (orb1737573)

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50 mg
¥ 910.00
1 ml x 10 mM (in DMSO)
¥ 1,170.00
100 mg
¥ 1,170.00
500 mg
¥ 1,560.00
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