CL2A-SN-38 DCA 1279680-68-0(free base)

SKU: orb1307468

Description

CL2A-SN-38 is a drug-linker conjugate designed for constructing antibody-drug conjugates (ADCs). It incorporates the topoisomerase I inhibitor SN-38 via a pH-sensitive, non-cleavable CL2A linker, enabling a bystander effect. This conjugate has demonstrated specific and significant antitumor activity in preclinical studies against various human solid tumor models.

Images & Validation

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Key Properties

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MW	1738.49
Purity	98.95% (May vary between batches)
Formula	C₇₇H₁₀₁Cl₄N₁₁O₂₆
SMILES	OC(=O)C(Cl)Cl.OC(=O)C(Cl)Cl.CCc1c2Cn3c(cc4c(COC(=O)[C@@]4(CC)OC(=O)OCc4ccc(NC(=O)[C@H](CCCCN)NC(=O)COCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCn5cc(CNC(=O)C6CCC(CN7C(=O)C=CC7=O)CC6)nn5)cc4)c3=O)-c2nc2ccc(O)cc12
Target	Others
Solubility	DMSO:10 mM

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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CL2A SN 38 DCA 1279680 68 0(free base), CL2ASN38 DCA 1279680680(free base), CL-2A-SN-38 DCA 1279680-68-0(free base), CL2A-SN-38 DCA 1279680-68-0(free base)

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Compound Identifiers

PubChem CID

155977520 ↗

Key Properties

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No computed properties available.

Protocol Information

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CL2A-SN-38 DCA 1279680-68-0(free base)

Description

Images & Validation

Key Properties

Storage & Handling

Alternative Names

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