CLEFMA

SKU: orb1685271

Description

CLEFMA is a small molecule research compound with demonstrated anti-proliferative activity, suppressing tumor growth in experimental models. Its mechanism involves NF-κB inhibition, leading to studied anti-inflammatory and anti-metastatic effects in both in vitro and in vivo cancer research.

Research Area

Cell Biology, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	1246964-32-8
MW	442.29
Purity	99.00% (May vary between batches)
Formula	C₂₃H₁₇Cl₂NO₄
SMILES	C(=C\1/C(=O)\C(=C\C2=C(Cl)C=CC=C2)\CN(C(/C=C\C(O)=O)=O)C1)\C3=C(Cl)C=CC=C3
Target	NF-κB,Apoptosis
Solubility	DMSO:60 mg/mL (135.66 mM)

Bioactivity

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Target IC50	H441 cells:6.4 μM\|A549 cells:8.9 μM
In Vivo	Daily intraperitoneal injection of 0.2-0.4 mg/kg CLEFMA for 4 weeks, CLEFMA inhibits tumor growth and FDG uptake in tumor tissue in a xenograft mouse model . In addition, CLEFMA downregulates the expression of anti-apoptotic markers cIAP1, Bcl-xL, Bcl-2, and survivin, and induces the cleavage and expression of the pro-apoptotic protein BID . Read more...
In Vitro	CLEFMA induces autophagic death in H441 cells. CLEFMA inhibits the viability of H441 and A549 cells, with IC50s of 6.4 and 8.9 μM, respectively. CLEFMA induces apoptosis and reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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antitumor, Apoptosis, anti-metastatic, anti-inflammatory, cancer, CLEFMA, curcuminoid, NF-kB, NFkB, NF-κB, NFκB, inhibit, Inhibitor

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Compound Identifiers

PubChem CID

46927962 ↗

Key Properties

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No computed properties available.

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CLEFMA (orb1685271)

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CLEFMA

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

CLEFMA (orb1685271)

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