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Clitocine

SKU: orb1697760

Description

Clitocine is a mushroom-derived adenosine analog that acts as a potent transcriptional readthrough agent, suppressing nonsense mutations and elevating p53 in relevant mutant cells. It also promotes TRAIL-induced apoptosis in colon cancer models through Mcl-1 degradation. NSC 81464 is a yohimbine-type alkaloid isolated from Rauwolfia vomitoria.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number105798-74-1
MW287.23
Purity≥95.0% (May vary between batches)
FormulaC9H13N5O6
SMILESNc1ncnc(N[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1[N+]([O-])=O
TargetBcl-2 Family,Apoptosis
SolubilityDMSO:80 mg/mL (278.52 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (11.49 mM)

Bioactivity

In Vivo
Induced by Citocine (0.3-3 mg/kg; s.c.; five times per week), p53 inhibits CAOV-33p53-UAA136 tumor growth in a xenograft model.
In Vitro
For premature stop codon readthrough activity, Clitocine incorporation into mRNA is required, and the presence of clitocine at the third position of a premature stop codon is sufficient to promote robust readthrough.Clitocine enhances TRAIL lethality in LS411N and SW620 cells, with concentrations ranging from 0 to 0.8 μM over a 24-hour period. Additionally, at a concentration of 0.2 μM for 36 hours, Clitocine significantly potentiates TRAIL-mediated apoptosis.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Clitocine, Apoptosis, Mcl-1
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Key Properties

No computed properties available.

Protocol Information

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1 mg
$ 240.00
DispatchUsually dispatched within 5-10 working days
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