Clopidogrel hydrogen sulfate

SKU: orb1310861

Description

Clopidogrel bisulfate is the active pharmaceutical ingredient of a potent antiplatelet agent. As a selective P2Y12 receptor antagonist, it inhibits ADP-induced platelet activation, fibrinogen binding, and aggregation. This compound is widely used in cardiovascular research, including in vitro platelet function studies and in vivo models of thrombosis and atherosclerosis.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	120202-66-6
MW	419.9
Purity	99.79%
Formula	C₁₆H₁₆ClNO₂S·H₂SO₄
SMILES	OS(O)(=O)=O.COC(=O)[C@@H](N1CCc2sccc2C1)c1ccccc1Cl
Target	Cytochromes P450,P2Y Receptor
Solubility	DMSO:250 mg/mL (595.38 mM)

Bioactivity

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Target IC50	CYP2B6:18.2 nM (IC50)\|CYP2C19:524 nM (IC50)
In Vivo	In RGM-1 cells, Clopidogrel (1 μM) inhibits the epidermal growth factor-induced activation of epidermal growth factor receptor, PERK expression, and cellular proliferation. Read more...
In Vitro	In a rat model of ulcer margins, daily administration of Clopidogrel (2 mg and 10 mg/kg) significantly reduced the proliferation of gastric epithelial cells induced by ulcers, as well as the expression of the EGF receptor and phosphorylated extracellular signal-regulated kinase. In rats with congestive heart failure, Clopidogrel enhanced the phosphorylation of AKT and eNOS, thereby improving vascular endothelial function and the bioavailability of nitric oxide. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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SR-25990C, CYP2C19, CYP2B6, Cytochrome P450, clot, Clopidogrel Bisulfate, Clopidogrel hydrogen, (S)-(+)-Clopidogrel bisulfate, (S)-(+)-Clopidogrel hydrogen sulfate, P2YReceptor, P2Y Receptor, P2Y

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Compound Identifiers

PubChem CID

115366 ↗

Key Properties

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No computed properties available.

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