Clopidogrel thiolactone

SKU: orb1689879

Description

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1147350-75-1
MW	337.82
Purity	98.79% (May vary between batches)
Formula	C₁₆H₁₆ClNO₃S
SMILES	COC(=O)[C@@H](N1CCC2SC(=O)C=C2C1)c1ccccc1Cl
Target	P2Y Receptor,Drug Metabolite
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.92 mM);Ethanol:2 mg/mL (5.92 mM);DMSO:30 mg/mL (88.8 mM)

Bioactivity

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In Vivo

Clopidogrel thiolactone holds great promise as a more potent and a safer antiplatelet agent that might have the following advantages over clopidogrel: (1) no drug resistance for CYP2C19 poor metabolizers; (2) lower dose-related toxicity due to a much lower effective dose; (3) faster onset of action. Clopidogrel thiolactone (8 μm/kg; i.v.; Sprague-Dawley male rats) exhibits good biological availability and pharmacokinetic parameters.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Clopidogrel thiolactone, 2-oxoclopidogrel, P2YReceptor, P2Y12, P2Y Receptor

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Compound Identifiers

PubChem CID

56848893 ↗

Key Properties

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No computed properties available.

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