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CMP-5

SKU: orb1710015

Description

CMP-5 is a potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5). It is a valuable research tool for investigating the role of PRMT5-mediated methylation in virology, including SARS coronavirus infection studies in vitro.

Research Area

Epigenetics & Chromatin, Immunology & Inflammation

Images & Validation

Key Properties

CAS Number880813-42-3
MW315.41
Purity98.68%
FormulaC21H21N3
SMILESCCn1c2ccccc2c2cc(CNCc3ccccn3)ccc12
TargetAntiviral,Histone Methyltransferase
SolubilityDMSO:100 mg/mL (317.05 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (15.85 mM)

Bioactivity

Target IC50
MTH2:9.2 μM|Th2 cells (human):31.6 μM|Th1 cells (human):26.9 μM |MTH1:3.7 μM|MTH1 (cells):3.7 μM |MTH2 (cells):9.2 μM |Th2 cells (human):31.6 μM |Th1 (human):26.9 μM
In Vitro
In 60A cells, CMP-5 (40 μM; 24 hours) inhibited the protein levels of p-BTK and pY(416)SRC.

Storage & Handling

StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CMP5, CMP-5, CMP 5, Antiviral, mTh1 cells, mTh2 cells, hTh1 cells, hTh2 cells, HistoneMethyltransferase, Histone Methyltransferase, PRMT5

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Quality Guarantee

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Key Properties

No computed properties available.

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CMP-5 (orb1710015)

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% DMSO +
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% Tween 80 +
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Available Sizes

Select a size below

1 mg
¥ 1,040.00
5 mg
¥ 1,820.00
1 ml x 10 mM (in DMSO)
¥ 1,950.00
10 mg
¥ 2,470.00
25 mg
¥ 3,770.00
50 mg
¥ 5,460.00
100 mg
¥ 7,670.00
500 mg
¥ 15,730.00
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