Cobolimab Antibody

SKU: orb1980299

Description

Cobolimab (TSR-022) is a high-affinity anti-TIM-3 monoclonal antibody that induces receptor internalization with an IC50 of 0.4464 nM. It demonstrates antitumor efficacy in preclinical research, supporting its investigation in models of advanced melanoma and hepatocellular carcinoma for both in vitro and in vivo studies.

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	2022215-65-0
MW	142.84 kDa
Purity	> 95%
Target	Others,Immunology/Inflammation related

Bioactivity

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Target IC50	TIM3:0.4464 nM
In Vitro	Cobolimab (0.0001-10 nM; 3 days) promotes dose-dependent internalization of TIM-3 in pre-activated T cells with an IC50 of 0.4464 nM, and at 20 µg/mL for 24 hours, significantly increases the content of CD8+ T cells by inhibiting TIM-3. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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GSK4069889, GSK-4069889, GSK 4069889, Cobolimab, TSR 022, TSR022, TSR-022

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Gene Symbol

Others,Immunology/Inflammation related

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